Preheat your oven to 350 degrees
In a large bowl add he ground beef, ketchup, Ritz crackers, breadcrumbs, salt, pepper, minced onion and garlic powder. Don't mix yet!
In a separate small bowl, whisk the egg and milk together. Add to the large bowl and mix all the ingredients together.
Split the meat mixture in half, adding one to an 8 x 4 loaf pan and the other to a freezer safe 8 x 4 loaf pan. OR add all the mixture to a 9 x 5 loaf pan. Make sure to make 3-4 slits in the top of each loaf.
Place the loaf on a foil lined baking sheet and bake for 45 minutes.
While the meatloaf is in the oven, combine the ketchup, brown sugar, jelly and Worcestershire sauce in a small bowl. Once the 45 minutes is up, spread half (or quarter if freezing a loaf) to the top of the loaf.
Place back in oven and cook for an additional 45 minutes. Let the meatloaf rest for 15 minutes to avoid it falling to pieces. *See notes for freezing instructions!